Co-exposure to cigarette smoke and alcohol decreases airway epithelial cell cilia beating in a protein kinase Cε-dependent manner.

Co-Exposure to Cigarette Smoke and AlcoholDecreases Airway Epithelial Cell Cilia Beating in aProtein Kinase CÎμ-Dependent Manner

Effects of Cigarette Smoke, Alcohol, Vitamin E and Vitamin C on Oral Mucosa and Salivary Peroxides Enzyme in Rats

Introduction: According to studies, high intake of fruits and vegetables are associated with reduced cancer incidence and mortality. The high levels of antioxidants in fruits and vegetables are believed to contribute in cancer prevention, possibly by inhibiting oxidative stress. This study aimed to investigate the effects of cigarette smoke, alcohol and vitamin E and vitamin C on oral mucosa an...

Gefitinib, an EGFR Tyrosine Kinase inhibitor, Prevents Smoke-Mediated Ciliated Airway Epithelial Cell Loss and Promotes Their Recovery

Cigarette smoke exposure is a major health hazard. Ciliated cells in the epithelium of the airway play a critical role in protection against the noxious effects of inhaled cigarette smoke. Ciliated cell numbers are reduced in smokers which weakens host defense and leads to disease. The mechanisms for the loss of ciliated cells are not well understood. The effects of whole cigarette smoke exposu...

Effects of cigarette smoke and alcohol on ciliated tracheal epithelium and inflammatory cell recruitment.

Ciliated epithelium represents the first line of host defense against lung infection. Most alcoholics smoke and are at high risk for developing lung infections. We reported that cigarette smoke activates protein kinase C (PKC) and alcohol desensitizes ciliary beat frequency (CBF) to beta-agonists in bovine bronchial epithelial cells in vitro. The combined effect of smoke and alcohol exposure on...

A histological study on the effects of aqueous extract of Althea officinalis on epithelial and submucosal mucocilliary system of rat trachea following inhalation of cigarette smoke

The contents of cigarette smoke (gaseous and solid phases) have been attributed to a variety of diseases in the respiratory and cardiovascular systems and have been associated with development of different types of cancers. In respiratory system, these compounds specially cause epithelial cell injury, and interfere with mucocilliary transport (MTC). Various parts of Althea officinalis (family M...